Winner
D3 – Southwest Regional
| Regional Semifinal | Regional Final |
|---|---|
| Georgetown | |
March 9, 2022  65-42  Trent Arena | |
| Georgetown | |
March 12, 2022 49-67 Trent Arena | |
| Meadowdale | |
| Mariemont | |
March 9, 2022  41-57 Trent Arena | |
| Taft | |
| Taft |
D3 Regional
| Regional Semifinal | Regional Final |
|---|---|
| Georgetown | |
March 9, 2022 65-42 Trent Arena | |
| Georgetown | |
March 12, 2022 49-67 Trent Arena | |
| Meadowdale | |
| Mariemont | |
March 9, 2022 41-57 Trent Arena | |
| Taft | |
| Taft |